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12 Diabetes Shares for Diabetes Consciousness Month

The Omnipod Sprint by Insulet.

November is American Diabetes Month. Dad and mom of youngsters with Sort 1 Diabetes snigger that it begins the day after Halloween. 

My 10-year-old son was identified in September 2021. 

Sort 1 Diabetes is an autoimmune dysfunction that sometimes presents earlier than age 25. It’s additionally referred to as Juvenile Diabetes, however a Sort 1 analysis can occur at any age.

It happens when the physique’s immune system assaults and kills the beta cells within the pancreas that produce insulin.

Insulin “unlocks” the physique’s cells, enabling them to soak up glucose and switch it into vitality.

With out insulin, Sort 1 Diabetics are in danger for diabetic ketoacidosis (DKA), a situation the place the physique burns fats cells for vitality, creating acidic ketones within the bloodstream. DKA is lethal.

The reason for Sort 1 Diabetes is unknown, however household historical past is a big threat issue. 

Sort 1 Diabetes:

  • isn’t preventable
  • isn’t reversible
  • requires insulin dependency for all times
  • analysis has nothing to do with food plan or life-style

The JDRF Sort 1 Diabetes Index estimates that the illness impacts 1.4 million Individuals and eight.7 million folks worldwide

Individuals with Sort 1 Diabetes should estimate carbs and calculate insulin doses for each meal for the remainder of their lives.

Sort 2 Diabetes often impacts folks over age 45. Threat components embody older age, extra weight, bodily inactivity, and poor food plan. 

The CDC estimates that 33-35 million Individuals have Sort 2 Diabetes. The illness is managed with improved food plan and life-style decisions, weight reduction, medicine, and insulin. 

Diabetes is manageable, enabling youngsters with Sort 1 to stay lengthy and wholesome lives. 

A number of investable firms create live-sustaining provides, applied sciences, and medicines to assist normalize the lives of individuals with diabetes. 

Diabetes Shares Overview

My son’s Sort 1 Diabetes has consumed my life and brainpower for the previous 12 months. Fortunately, we’ve improved at managing his blood sugar utilizing a steady glucose monitor (CGM) and insulin pumps.

But it surely takes work, particularly as he shortly grows and exits the honeymoon section (when the pancreas nonetheless produces some insulin).

I’ve accompanied my son by way of analysis, numerous finger-pricks, day by day pictures, CGMs, pumps, and system knowledge, and navigated the prices and insurance coverage trickery by way of all of it.

This expertise has given me perception into firms and applied sciences enabling folks with diabetes to stay considerably regular lives. 

As an investor, this provides me some distinctive perception.

The record of # diabetes shares isn’t a advice to purchase or promote any of them.

The aim of this text is to increase consciousness for Sort 1 Diabetes.

I’m grateful for these firms that empower us to handle his situation. We’re enthusiastic about new applied sciences and breakthroughs and longing for an eventual treatment. 

I’ve divided the record of diabetes shares into three classes:

  • Machine and Provide Makers
  • Insulin Producers
  • Treatment Seekers

Diabetes Shares: Machine and Provide Makers

Individuals with diabetes depend on a number of gadgets and disposable provides to get by way of every day. 

When my son left the hospital, we carried a bag stuffed with about $2,000 price of medication and provides.

Getting snug with insulin pens, needles, blood glucose meters, kinds of insulin, and find out how to reorder every part took a number of weeks and prompted plenty of anxiousness.

And that was earlier than he received any wearable gadgets. Now we’re nearly consultants on these things.

Listed here are the businesses. 

1. Dexcom (DXCM)

Picture of Dexcom G6 3-pack box and transmitter.

The Dexcom G6. Applicator (with orange button), sensor, and transmitter.

Dexcom is a diabetes administration firm that manufactures steady glucose displays (CGMs).

CGMs present blood glucose readings to customers each 5 minutes. 

Earlier than CGMs, folks with diabetes wanted to finger prick earlier than each meal and when not feeling nicely. 4 or 5 finger pricks a day tells a really abbreviated story. 

The Dexcom G6 CGM offers 288 blood glucose day by day readings, telling a whole story of blood glucose ranges.

CGMs are additionally predictive, giving customers warnings for low or excessive blood glucose ranges.

Hypoglycemia (low blood sugar brought on by an excessive amount of insulin) will be an emergency.

Hyperglycemia (not sufficient insulin) causes long-term well being points. 

Dexcoms have almost turn out to be commonplace care for kids with Sort 1 Diabetes as a result of mother and father can monitor blood sugar remotely and at evening.

Customers insert a sensor into the interstitial fluid underneath the pores and skin. The sensor calculates a surprisingly correct blood glucose studying.

An connected transmitter then relays every studying to a receiving system (often a smartphone), and the Dexcom smartphone app shows the studying and shares it with followers. 

Right here’s a snapshot from my telephone. The large quantity is the most recent blood glucose studying. The arrow signifies the pattern, which helps to foretell highs and lows. 

Dexcom CGM screenshot. Dexcom is one of 12 diabetes stocks on our list.

70-180 vary is right. Decrease is usually higher, however not too low. A spike happens after most meals. 

Sufferers share the info with their endocrinologists and diabetes nurses. Knowledge sharing is a robust device for managing the illness.

Our son will doubtless put on this or an analogous system almost 24/7 for the remainder of his life. Over time, they’ll get cheaper, smaller, and extra correct.

CGMs require a prescription within the U.S., however in some nations, you should purchase CGMs over-the-counter. Well being nuts have an interest within the knowledge. 

Dexcoms are usually not low-cost. The system lasts ten days, in order that’s about 36 gadgets per 12 months, they usually value about $100 a chunk, plus 4 transmitters per 12 months. Insurance coverage covers most of this value for us, however hundreds of thousands worldwide do not need entry to CGMs. 

Musician Nick Jonas is a Dexcom spokesperson.

Right here’s an Instagram publish by Australian mannequin Bambi Northwood-Blyth inserting her Dexcom G6 sensor. We do that each ten days, often on my son’s higher butt (extra to the fitting than hers). 

In its October 2022 quarterly earnings convention name, Dexcom indicated it expects FDA approval for the G7 by the tip of 2022. The system is 60% smaller, simpler to insert, and cheaper to fabricate.

The Dexcom G7 is already obtainable within the U.Ok. and elsewhere. Its U.S. launch is predicted to be a catalyst for the inventory.

My son likes a YouTuber referred to as Nerdabetic, who’s everywhere in the new system. 

2. Insulet (PODD)

Insulin pumps make the lives of diabetics simpler.

As a substitute of taking a number of day by day insulin injections, insulin pumps do the job with a number of faucets.

Pumps provide you with a lot better management over insulin supply and allow youngsters to eat like rising youngsters eat — incessantly. 

The Omnipod by Insulet is an unimaginable system. 

It’s the one FDA-approved “tubeless” insulin pump. The system sticks to the pores and skin and inserts a little bit tube underneath the pores and skin, which delivers the insulin. 

Tubeless supply works properly for our son. He’s a swimmer, and the Omnipod goes within the water with him and retains working. 

The consumer applies a model new system each 2-3 days, altering physique location every time to make sure the insulin is delivered correctly.

Omnipods are disposable. 

Mannequin Lila Grace Moss proudly sports activities her Omnipod on the runway (left hip space). 

Right here’s a closeup of 1 utilized by my son. It’s in regards to the dimension of an Apple AirPod case. On the underside, you may see the cannula (little tube) that inserts underneath his pores and skin.

Picture of the Omnipod dash from the top and bottom.

Omnipod Sprint

There’s a cool YouTube video of an engineer who disassembles the Omnipod to see the way it works inside. Extraordinary.  

This 16-year-old Ninja Warrior, Kate Boone, reveals off her Dexcom and Omnipod as she plows by way of this insane impediment course. You possibly can see each gadgets on the again of her arms. 

The newest model, the Omnipod 5, communicates with the Dexcom and may ship insulin based mostly on the CGM readings, predictively avoiding highs and lows. 

The mixture of CGMs and insulin pumps is getting us near having an “synthetic exterior pancreas”. Nevertheless, the insulin pumps can’t inform what number of carbs you eat. You must sort that into the system. 

Insurance coverage firms just like the Omnipod due to the decrease upfront value and disposability. Different pumps require a excessive upfront value for the system, which is dear to interchange if it breaks. 

Representatives from Insulet will ring the closing bell on the Nasdaq on November 14th, World Diabetes Day. 

3. Tandem Diabetes Care (TNDM)

Tandem is one other pure-play diabetes firm that makes a well-liked insulin pump referred to as the t:slim.

The t:slim line of pumps was the primary to combine with CGM knowledge, informing an algorithm to assist management blood glucose ranges. 

All of the customers I’ve spoken to like the t:slim. Particularly the way it robotically adjusts basal insulin (baseline) for highs and lows. 

The picture under reveals the t:slim system linked through tubing to an infusion set that inserts a cannula underneath the pores and skin. The system hangs on a belt or goes in a pocket.

On the fitting is a Dexcom G6.

Picture of Tandem t:slim next to a Dexcom G6. Two diabetes stocks featured in our list.

Picture Supply: Tandem Diabetes

Having a robust system all the time linked offers the consumer wonderful management of their insulin supply.

Nevertheless, the system isn’t waterproof, so insulin supply have to be disconnected throughout swimming and showering. 

Disconnection stops the move of basal (baseline) insulin and may trigger blood sugar highs. 

The t:slim has the next upfront value in comparison with the Omnipod. The little system within the image above is a number of thousand {dollars}. Most insurance coverage solely covers that value as soon as each 4 or so. 

Omnipod’s management system is a small modified smartphone. It solely must be close by when sending the pump directions. 

Customers inform me the t:slim is a superb system, and the tube hardly ever will get in the way in which. However a toddler consumer I do know struggled with it whereas enjoying sports activities and swimming and has since transitioned to the Omnipod 5. 

Tandem has its personal “tubeless” insulin pump referred to as the Mobi: Tubeless within the product pipeline.

4. Abbott Labs (ABT)

Abbott Labs is a Dividend Aristocrat inventory, having paid and raised its dividend for greater than 25 years. It’s additionally a member of the elite Dividend Kings record, having elevated its dividend for 50 years.

Abbott has a line of blood glucose displays underneath the FreeStyle moniker. 

The FreeStyle Libre is the first U.S. competitor to Dexcom. It began as a “flash” monitoring system the place you’d maintain a reader system close to the skin-attached system to get a studying. It wasn’t steady. 

Nevertheless, the FreeStyle Libre 3 was authorised by the FDA in Might 2022. It performs equally to the Dexcom with steady monitoring and Bluetooth transmittal to a smartphone. 

The FreeStyle Libre is smaller than the Dexcom G6 and usually prices much less for insurers. Dexcom’s G7 ought to be extra aggressive in dimension and value. 

Wholesome competitors and innovation between the 2 U.S. leaders ought to assist to drive long-term prices down.

New entrants catering to non-diabetics and worldwide producers might additionally come into play if they will navigate the FDA approval course of. 

5. Embecta (EMBC)

Embecta is a “pure play” diabetes inventory. The corporate “gives time-trusted merchandise now with a singular give attention to diabetes care.”

Its merchandise embody insulin pen needles, insulin syringes, a diabetes care app, and diabetes equipment. 

Embecta is a current spinoff from Becton Dickinson (BD), one other Dividend Aristocrat. Becton Dickinson is a greater than 100-year-old firm and was an early producer of diabetes provides, together with syringes.

As a by-product paying a dividend, Embecta might be a part of the Dividend Aristocrats record in January so long as it continues to pay and enhance its dividend.   

Individuals with diabetes who don’t use a pump (most) do a number of day by day injections (MDI) of insulin. And each time, they want a brand new syringe or needle. 

BD is essentially the most well-known maker of those needles. And when you begin utilizing a model for this function, there’s little incentive to alter.

Contemplating the robust model recognition and secure buyer base (customers for all times), Embecta will doubtless be a gentle and boring enterprise for years to return.

Numerous traders like boring firms.

Right here’s a pattern of what we introduced dwelling from the hospital.

Sample of supplies we brought home from the hospital. Several diabetes stocks represented here.

6. Medtronic (MDT)

Medtronic is a Dividend Aristocrat that has been a secure holding for dividend traders over time. The corporate has a number of merchandise within the diabetes area, together with a line of insulin pumps and a CGM. 

Their pumps and CGM are much less widespread amongst Sort 1 youngsters than the manufacturers I’ve mentioned above. 

Nevertheless, Medtronic’s Sensible Insulin Pen is among the many finest within the market. 

Diabetics not on an insulin pump usually use “pens” for injections. Pens are simpler to make use of than commonplace insulin syringes. 

The consumer inserts an insulin cartridge into the pen, then attaches a contemporary BD needle for every injection. The pen has a small dial to set a exact dose which is injected with the press of a button.

Medtronic’s InPen sends knowledge to a smartphone app that helps to calculate doses, observe historical past, and show info. 

We used an analogous pen referred to as the NovoPen Echo for the primary seven months of diabetes administration. 

Diabetes Shares: Insulin Producers

In case you observe the information, you may have heard in regards to the excessive prices of insulin. Legislators tried to move a legislation to cap insulin prices for all Individuals at $35 per thirty days (out of pocket) through the Inflation Discount Act (IRA).

Half of Congress rejected that provision and solely handed the price restrict for insulin customers on Medicare.

Our household has solely paid a $20 copay for our son’s month-to-month provide. We’ve got lots, and the price barely scratches our finances.

We’ve got nice medical insurance because of my beneficiant employer

However for these with out insurance coverage, it may be pricey, inflicting folks to ration insulin or use expired, much less efficient medication. 

The excessive prices are perplexing since insulin has been round for 100 years. 

Insulin was found within the early Twenties by a group on the College of Toronto. The inventors licensed their patents and allowed different firms to patent enhancements. 

Patents on the main insulin varieties lastly expired in 2014, however the formulation are troublesome to duplicate and wish FDA approval, in accordance with Johns Hopkins

Three producers dominate the market, giving them negotiation benefits with the insurance coverage firms and letting them cost what they wish to anybody else that wants insulin. 

Listed here are the three diabetes shares and their widespread insulin manufacturers:

7. Novo Nordisk (NVO)

Insulin manufacturers:  Novalog, Novalin, Fiasp, Tresiba

8. Sanofi SA (SNY)

Insulin model: Lantus

9. Eli Lilly (LLY)

Insulin manufacturers: Humalog, Basaglar

Our son’s Endocrinologist prescribed Humalog (bolus, short-acting) and Basaglar (long-acting) made by Eli Lilly. 

The insurance coverage firm “most popular” these medicine, which makes me shudder realizing that insurance coverage executives influenced my son’s therapy. 

Generics are on the horizon. A non-profit referred to as Civica Rx is constructing a generic insulin facility in Petersburg, Virginia, that ought to produce insulin at $30 for a month-long provide by 2024.

Mark Cuban and his Price Plus Medication may assist decrease the price. The corporate has just lately moved into the diabetes area, partnering with Roche to offer Accu-Chek blood glucose meters and check strips. 

Search “Mark Cuban Insulin” or “Mark Cuban CGM” on Twitter, and also you’ll see how determined individuals are for lower-cost insulin and gadgets. 

Diabetes Shares: Treatment Seekers

We met my son’s Endocrinologist the morning after his analysis. The very first thing she mentioned to us was she is for certain {that a} treatment for Sort 1 Diabetes will turn out to be obtainable in his lifetime. 

However there’s a saying within the Sort 1 Diabetes neighborhood {that a} treatment is all the time 5 years away.

A member of the family works in biotechnology and says that firms desire therapies over cures. 

The biggest firms give attention to therapies as a result of life-long ailments and medicines to handle them create wonderful money move. 

As an investor, that’s nice. 

However as a T1D Dad, I like seeing analysis and commercialization of potential cures. 

With developments in medication, genetics, and healthcare over the previous 100 years, scientists could be close to a treatment. 

Cures are all the time tough and require analysis grants, experimentation, and costly scientific trials earlier than approval. 

A Sort 1 Diabetes treatment would doubtless require two steps:

  • Restore or change the cells killed by the immune system
  • Suppress the immune response to stop the physique from attacking the brand new cells

Innovation over the previous 20 years might make this potential. Nevertheless, docs, mother and father, and sufferers should take into account the dangers and prices earlier than getting it performed. 

Just a few firms I do know of are engaged on totally different long-term therapies and possibly even a treatment. 

10. Vertex Prescribed drugs (VRTX)

Vertex Prescribed drugs is a $75 billion pharmaceutical firm and chief in therapies for cystic fibrosis. 

The corporate has made two daring acquisitions within the Sort 1 Diabetes area previously few years.

The primary was Semma Therapeutics in September 2019. 

Semma was a venture-backed startup funded by the JDRF T1D Fund. Semma pioneered a beta cell substitute method utilizing stem cells. 

In October 2021, Vertex introduced better-than-expected leads to a Part 1/2 trial of its VX-880, a stem cell-derived pancreatic islet cell substitute remedy for Sort 1 Sufferers. 

The therapy cured a 64-year-old man identified with Sort 1 Diabetes 40 years earlier. 

The New York Instances profiled the person’s story (or learn this model if you happen to hit a paywall).

Vertex dove deeper into discovering a treatment for Sort 1 Diabetes in July 2022 when it acquired its major Sort 1 Diabetes stem cell remedy rival, ViaCyte.

ViaCyte has a scientific trial of its personal underway with the FDA. 

Buying ViaCyte’s experience, check services, and mental property ought to assist Vertex transfer nearer to a commercialized treatment for Sort 1 Diabetes. 

There’s nonetheless plenty of work, trials, and FDA hurdles earlier than therapies turn out to be commonplace. However seeing constructive scientific trials is a constructive signal that sooner or later my son might obtain therapy to treatment him of this situation. 

A brand new movie was launched final week referred to as The Human Trial about chasing the treatment for Sort 1 Diabetes.

Right here’s a trailer. 


11. CRISPR Therapeutics (CRSP)

The stem cell therapies have proven efficacy and the potential to interchange the beta cells that create insulin within the pancreas. Nevertheless, if the cells have the identical genetic markup as the unique cells, the immune system will assault and kill them once more. 

Sufferers must take immunosuppressant medicine to stop this from taking place. These medicine have important unwanted effects which will deter Sort 1 Diabetics from getting the therapy. 

The Nobel Prize-winning CRISPR expertise empowers researchers to alter cell DNA. The expertise could also be relevant to quite a lot of illness classes. 

In a possible Sort 1 Diabetes treatment, the expertise might assist to change the genetic code of the substitute beta cells to keep away from the physique’s immune response, thus, eliminating the necessity for immunosuppressant medicine and enabling a full treatment. 

CRISPR Therapeutics, although public, has little income at this level. However affected person progress inventory traders may even see its potential.

12. Genprex (GNPX)

One closing firm additionally engaged on a treatment is Genprex. 

Genprex has an unique licensing settlement with the College of Pittsburgh for the gene remedy work being performed by Dr. George Gittes. Gittes is a pediatric surgeon who turned all for how pancreas cells develop and develop. 

He and his group have developed a method to ship gene remedy to the pancreas through viruses. He and his group have developed a method to ship gene remedy to the pancreas through viruses.

The therapy modifies among the non-insulin-producing cells within the pancreas to start out making them produce insulin.

In trials with mice, the process labored. However much more thrilling, the immune system didn’t discover the cells for a very long time.

The Gittes Lab on the College of Pittsburgh is now attempting this remedy in monkeys. Most of his work has been funded by grants from the Nationwide Institutes of Well being (NIH).

When ample preclinical knowledge is generated from these trials, the group will accomplice with Genprex to design and start a Part 1 scientific trial in diabetic sufferers. Genprex is skilled in scientific trials and navigating FDA purple tape. 

Here’s a video of Dr. Gittes describing the gene remedy process.

Genprex is a pre-revenue microcap firm, making it an especially dangerous and speculative funding not appropriate for many traders.

Diabetes Shares Abstract

As a reminder, this text isn’t about recommending shares. It’s about elevating consciousness for Sort 1 Diabetes and highlighting the businesses making the lives of individuals with diabetes simpler. 

Please carry out due diligence earlier than investing in any of the shares talked about. 

Right here’s a abstract of the 12 diabetes shares talked about on this article. 

TABLE UPDATED 11/10/2022
DXCM Dexcom 120.07 46134668407 211.5 102.86
PODD Insulet Company 306.41 21167962912 619.6 210.21
TNDM Tandem Diabetes Care 39.26 2520833787 91.6
ABT Abbott Labs 103.12 179744934184 22.34 1.88 22.65 0.0189
EMBC Embecta 30.63 1755048552 4.84 0.6 9.09 0.0212
MDT Medtronic 81.35 108551923076 20.5 2.72 13.54 0.0343
LLY Eli LIlly 366.98 348126147003 57.97 3.92 39.12 0.0108
SNY Sanofi 44.54 112208305456 17.24 1.75 9.86 0.0403
NVO Novo Nordisk 116.15 201584651048 39.02 1.6 3.96 0.014
VRTX Vertex Pharamaceuticals 311.6 79302241742 24.41 19.59
CRSP CRISPR Therapeutics 52.91 4065814714
GNPX Genprex 1.33 63530854

Photographs by RBD except marked in any other case. The creator is lengthy DXCM, PODD, ABT, VRTX, CRSP, and GNPX.


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